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See the end of this leaflet for a complete list of ingredients in VIAGRA.

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Blood pressure was measured after administration of VIAGRA at the same times as those specified for the first doxazosin study.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.A total dose of 40 mg sildenafil was administered by four intravenous infusions.

REVATIO is used to treat a rare disease called pulmonary arterial hypertension (PAH).The following adverse reactions have been identified during post approval use of VIAGRA.The important element of cheap generic Viagra is sildenafil citrate.Physicians should discuss with patients the potential cardiac risk of sexual activity in patients with preexisting cardiovascular risk factors.In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil C max.The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers.In the second study, a single oral dose of VIAGRA 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH.Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.

The safety and efficacy of combinations of VIAGRA with other PDE5 Inhibitors, including REVATIO or other pulmonary arterial hypertension (PAH) treatments containing sildenafil, or other treatments for erectile dysfunction have not been studied.

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Effects of VIAGRA on Cardiac Parameters: Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers.The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 100 mg VIAGRA or matching placebo are shown in Figure 4.

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Patients should stop VIAGRA and seek prompt medical attention in the event of sudden decrease or loss of hearing ( 5.4 ).Abnormal Vision: Mild to moderate in severity and transient, predominantly color tinge to vision, but also increased sensitivity to light, or blurred vision.

When a single 100 mg dose of VIAGRA was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 160% increase in sildenafil C max and a 182% increase in sildenafil AUC.Efficacy Results in Subpopulations in Controlled Clinical Studies.Mean sildenafil plasma concentrations measured after the administration of a single oral dose of 100 mg to healthy male volunteers is depicted below.

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Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours after VIAGRA or matching placebo.Caution is advised when VIAGRA is co-administered with alpha-blockers or anti-hypertensives.Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex.After patients have taken VIAGRA, it is unknown when nitrates, if necessary, can be safely administered.

Sildenafil at recommended doses has no effect in the absence of sexual stimulation.Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs.

At doses above the recommended dose range, adverse reactions were similar to those detailed in Table 1 below but generally were reported more frequently.Sexual function data were also recorded by patients in a daily diary.

Most, but not all, of these patients had preexisting cardiovascular risk factors.A causal relationship between VIAGRA and these events has not been established.

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Patients should be stable on alpha-blocker therapy prior to initiating a PDE5 inhibitor.The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse.

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